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Vidya Perera
Ethnic differences in CYP1A2 activity
My project aims to look at ethnic differences in CYP1A2 enzyme activity between people of Indian and European origin. CYP1A2 is responsible for the metabolism of numerous antipsychotic and antidepressant medications whilst also being involved in the metabolic conversion of carcinogenic compounds. The project will look at all aspects of ethnicty including genetics, environment and culture in order to pinpoint the factors responsible for drug response variability.
Primary Supervisor: Professor Andrew McLachlan
Associate Supervisor: Associate Professor Annette Gross
Degree: Doctor of Philosophy
Gynostemma pentaphylum saponins as anti-atherosclerotic agents
Molecular modelling studies to aid in the selection of anti-atherosclerotic gypenosides derived from Gynostemma pentaphyllum. more...
Supervisor(s):
Research Location:
Program Type:
N/A
Keywords:
atherosclerosis, cardiovascular disease, hyperlipidaemia, cholesterol metabolism, molecular modelling, separation science, spectroscopic analyses, phytochemistry, Biochemistry, Cell biology, Cardiovascular & respiratory diseases, Therapeutics & adverse drug effects, Heart & circulation, Pharmacology & therapeutics
Coating on Titanium Implant as a Drug Delivery Device
The project could enhance the success rate of metallic implants by increasing the implant/host tissue interfacial strength and stability, particularly in case of hip joint implants, reducing both implant failure rate and the need for revision surgery.. more...
Supervisor(s):
Research Location:
Advanced Drug Delivery Group, Faculty of Pharmacy
Program Type:
N/A
Keywords:
Movement Disorder, Therapeutics & adverse drug effects, Organ replacement, Drug Delivery Device, Biomedical Implants, Biomaterials, Bone, tissue engineering, Pharmacology & therapeutics, Movement
Informatics and Bioinformatics-based Approaches to Protein-Ligand Interaction
The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes.. more...
Supervisor(s):
Research Location:
Program Type:
N/A
Keywords:
Bioinformatics, sequence analysis, Crystallisation, protein structure, drug design, inhibitors, rational drug design Schizophrenia, inflammation, Cancer
Molecular regulation of the human cytochrome P450 (CYP) 2J2 fatty acid epoxygenase gene by GATA transcription factors
This project will explore our novel finding that the zinc-finger GATA factors are important transactivation regulators of the human cytochrome P450 2J2 (CYP2J2) fatty acid epoxygenase which has a critical role in cell survival in health and disease.. more...
Supervisor(s):
Research Location:
Pharmacogenomics and Drug Development, Faculty of Pharmacy
Program Type:
N/A
Keywords:
ischaemia-reperfusion injury, cardiovascular system, infarction, Stroke, cytochrome P450, fatty acid epoxygenation, ischaemic injury, GATA factors, gene regulation, Therapeutics & adverse drug effects, Cell biology, Pharmacology & therapeutics
New epidermal growth factor receptor (EGFR) inhibitors for the treatment of cancer
Molecular modelling and synthesis and characterisation of the hit compounds, biological testing in cell based assays and the determination of the inhibition of receptor dimerisation using gel electrophoresis and Western blotting.. more...
Supervisor(s):
Hibbs, David (Dai) (Associate Professor)
Research Location:
Program Type:
N/A
Keywords:
EGFR dimerisation, cytotoxicity., Cancer treatment, Cell proliferation
Novel inhalation formulation to improve quality of life of cystic fibrosis sufferers
The proposed research project aims to devise a novel dual-action aerosol formulation to be delivered directly to the site of the disease and that could be efficacious on both the major symptoms presents in cystic fibrosis patients: the build up of thick mucus and the bacterial inflammation.. more...
Supervisor(s):
Research Location:
Advanced Drug Delivery Group, Faculty of Pharmacy
Program Type:
N/A
Keywords:
Cystic fibrosis, Inhalation, Aerosols, Dry Powder Inhalers, Therapeutics & adverse drug effects, Cardiovascular & respiratory diseases, Chronic diseases & ageing, Genetic disorders, Infectious diseases, Genes in biology & medicine, Infection & immunity, Pharmacology & therapeutics, Respiration
Pharmacogenetics of individualised anti-cancer drug therapy.
Cytochrome P450 (CYP) enzymes control drug elimination and determine whether therapeutic serum concentrations of anticancer drugs can be achieved in patients.. more...
Supervisor(s):
Research Location:
Pharmacogenomics and Drug Development, Faculty of Pharmacy
Program Type:
N/A
Keywords:
Cancer, chemotherapy, personalized medicine, cytochrome P450, anti-cancer drugs, clearance, genotyping, mass-spectrometry, Therapeutics & adverse drug effects, Cancer & leukaemia, Cell biology, Pharmacology & therapeutics
Structure-based drug design with Kynurenine Aminotransferase-I
Human kynurenine amino transferase (KAT-1) forms the basis of a structure-based drug design study with implications for schizophrenia.. more...
Supervisor(s):
Research Location:
Program Type:
N/A
Keywords:
Schizophrenia, Crystallisation, protein, complex, structure, drug design, inhibitors, rational drug design, Brain & nervous system disorders, Therapeutics & adverse drug effects, Cell biology, Genes in biology & medicine, Pharmacology & therapeutics
Medicinal and Pharmaceutical Chemistry — Design, Synthesis and Testing of Novel Anti-Cancer Agents
Are you interested in applying your laboratory expertise to the development of new drugs for cancer and other diseases? Become part of a multi-disciplinary team involved in drug discovery. more...
Supervisor(s):
Groundwater, Paul (Professor), Hibbs, David (Dai) (Associate Professor)
Research Location:
Program Type:
Masters/PHD
Keywords:
EGFR, medicinal, pharmaceutical, chemistry, synthesis, Cancer, agents, receptors, cytotoxicity, cell
Medicinal and Pharmaceutical Chemistry — Design, Synthesis and Testing of New Anti-Bacterial Agents
This project would appeal to those with interests in pharmaceutical applications of medicinal and protein chemistry.. more...
Supervisor(s):
Groundwater, Paul (Professor), Church, Bret (Dr), Hibbs, David (Dai) (Associate Professor)
Research Location:
Program Type:
Masters/PHD
Keywords:
Anti-bacterial, pharmaceutical chemistry, respiratory, Cystic fibrosis, Cancer, antibiotics, protein, synthesis, testing, agents, pharmacy